Escin IA;Aescin IA( —— )

Catalog No. M21436 CAS No. 123748-68-5

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Product Name

Escin IA;Aescin IA
Note

Research use only, not for human use.
Brief Description

Escin IA is a triterpene saponin isolated from horse chestnut which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.
Description

Escin IA is a triterpene saponin isolated from horse chestnut which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV-1 protease
Research Area

——
Indication

——

CAS Number

123748-68-5
Formula Weight

1131.3
Molecular Formula

C55H86O24
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (88.40 mM)
SMILES

C/C=C(\C)/C(=O)O[C@H]1[C@@H]([C@@]2([C@@H](C[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)[C@@H]2CC1(C)C)C)O)CO)OC(=O)C
Chemical Name

——

1.Yang XW et al. Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis. J Nat Prod. 1999 Nov;62(11):1510-3.

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